Translational Research

Researchers at the Indiana University School of Medicine are engaged in a wide range of translational research that advances basic scientific discoveries into solutions for patient care.

The major focus of current research includes cancer, cardiovascular disease, health informatics/personalized medicine, metabolic disease, neuroscience, and regenerative medicine. Innovations from these and other research endeavors are translated into new therapies and technologies to improve human health.

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Technology that creates blood vessels

The technology was developed by Dr. Mervin C. Yoder, the Richard and Pauline Klinger Professor of Pediatrics and professor of biochemistry and molecular biology . The technology creates cells that are injected in a gel material directly into a limb to encourage the regeneration of small blood vessels. Users also can use 3-D bioprinting to make the cells necessary to create artificial blood vessels that can be transplanted into the limb.

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Hal E. Broxmeyer, Dept of Microbiology and immunology

Life in the blood

Professor Hal E. Broxmeyer, a leading researcher in blood-related diseases. He is internationally recognized as a scientific pioneer in the field of umbilical cord blood stem cell transplantation.

His laboratory focuses on mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, embryonic, and induced pluripotent stem cells at cellular, intracellular, and animal levels, as well as gene transfer, to influence these functions.

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Wade_Clapp_Prof. Of Pediatrics

New treatments for inherited cancers

Professor Wade Clapp is a leaders in neurofibromatosis research. Neurofibromatosis type 1 is the most common genetic disease with a predisposition to cancer and one of a series of developmental disorders called Rasopathies that have a range of malignant, neurodevelopmental and other non-malignant disease manifestations.

Has been selected to lead a five-year, $12 million national research project to develop new treatments for diseases of a genetic mutation that leads to disfiguring and life-threatening tumors and other developmental disorders, mainly in children.

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Andrew_Saykin_neuroscience_Prof

Alzheimer’s Disease Gene-to-Drug Initiative

Internationally recognized research investigators at IUSM identified a gene associated with Alzheimer’s disease. Using samples from participants in the national Alzheimer’s Disease Neuroimaging Initiative, the team conducted an analysis of biomarkers in cerebrospinal fluid that could be used for early detection of Alzheimer’s disease.

A new gene-to-drug initiative is now under way to translate disease-associated gene discovery to identify drugs to treat disease in collaboration with industry partners.

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Raghu Mirmira, M.D., Ph.D.

New Diabetes Research Center

The diabetes research team at IUSM is engaged in research for developing new therapeutic approaches. IUSM researchers Raghu Mirmira, M.D., Ph.D., and Carmella Evans-Molina, M.D., Ph.D., are focused on basic and translational research in diabetes centered upon Islet cell biology.

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Ching-Pin Chang, M.D., Ph.D

Epigenetics of Heart Failure

Ching-Pin Chang, M.D., Ph.D., director of molecular and translational medicine at IUSM’s Krannert Institute of Cardiology, has identified new epigenetic molecular pathways that may serve as novel targets for drug development for heart failure.

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Anantha Shekhar, Raymond E. Houk Professor of Psychiatry

Post-Traumatic Stress Disorder

IU scientists from across the university are working together to prevent post-traumatic stress disorder (PTSD). Anantha Shekhar, Raymond E. Houk Professor of Psychiatry, and an interdisciplinary team of researchers identified two compounds that disrupt a brain pathway that is stimulated by traumatic experiences. These compounds could potentially offer a way to prevent long-term PTSD symptoms.

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